Rec8 ELISA Kit for Mouse(Mus musculus) | EIAab.comRec8 ELISA Kit for Mouse(Mus musculus)

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Rec8 (Gene name),

Meiotic recombination protein REC8 homolog (Protein name ), REC8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rec8(Mei8;Rec8L1);

Protein name:

Meiotic recombination protein REC8 homolog;

Alternative:

Cohesin Rec8p;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51.

Function:

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

Subcellular Location:

Nucleus Chromosome Chromosome centromere In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.

Protein Attributes:

Sequence length:

591

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

591:

PRKLASRVFY | LLLVLSTQKI | LLVEQQKPYG | PLLIRPGPKF | P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8C5S7

KEGG:

mmu:56739

SMR:

Q8C5S7

Pfam:

PF04824

STRING:

10090.ENSMUSP00000002395

UniGene:

Mm.23149

Uniprot:

Q8C5S7

FOR

ELISA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

E4955h

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Manual:

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96T

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ELISA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

E4955m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

E4955r

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Packing:

96T

CLIA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

U4955r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

U4955h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Meiotic recombination protein REC8 homolog

Cat.:

U4955m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Meiotic recombination protein REC8 homolog

Cat.:

P4955Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Meiotic recombination protein REC8 homolog

Cat.:

P4955Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Meiotic recombination protein REC8 homolog

Cat.:

P4955Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Meiotic recombination protein REC8 homolog

Protein for Mouse Meiotic recombination protein REC8 homolog

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"mrec8, a meiotic homolog of the rad21 cohesin family."
Beasley M. , Warren W. , McKay M.J.
Submitted (2000-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Testis.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Embryo.
4.

"Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans."
Parisi S. , McKay M.J. , Molnar M. , Thompson M.A. , van der Spek P.J. , van Drunen-Schoenmaker E. , Kanaar R. , Lehmann E. , Hoeijmakers J.H.J. , Kohli J.
Mol. Cell. Biol.19:3515-3528(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis."
Prieto I. , Pezzi N. , Buesa J.M. , Kremer L. , Barthelemy I. , Carreiro C. , Roncal F. , Martinez A. , Gomez L. , Fernandez R. , Martinez-A C. , Barbero J.L.
EMBO Rep.3:543-550(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
6.

"Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice."
Lee J. , Yokota T. , Yamashita M.
Zool. Sci.19:539-544(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis."
Lee J. , Iwai T. , Yokota T. , Yamashita M.
J. Cell Sci.116:2781-2790(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMC1B; SMC3 AND SYCP3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION
8.

"Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8."
Bannister L.A. , Reinholdt L.G. , Munroe R.J. , Schimenti J.C.
Genesis40:184-194(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis."
Xu H. , Beasley M.D. , Warren W.D. , van der Horst G.T.J. , McKay M.J.
Dev. Cell8:949-961(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
10.

"Loss of Rec8 from chromosome arm and centromere region is required for homologous chromosome separation and sister chromatid separation, respectively, in mammalian meiosis."
Lee J. , Okada K. , Ogushi S. , Miyano T. , Miyake M. , Yamashita M.
Cell Cycle5:1448-1455(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis."
Fukuda T. , Pratto F. , Schimenti J.C. , Turner J.M. , Camerini-Otero R.D. , Hoeoeg C.
PLoS Genet.8:E1002485-E1002485(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION

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